Attention-deficit hyperactivity disorder may be associated with decreased central brain-derived neurotrophic factor activity: clinical and therapeutic implications

SJ Tsai - Medical hypotheses, 2007 - Elsevier
Attention-deficit hyperactivity disorder (ADHD) is a common childhood psychiatric disorder.
Despite intensive research efforts, the aetiology of ADHD remains unknown. Current
evidence suggests that the aetiology of ADHD is heterogeneous, comprising of multiple
factors. Recently, it has been proposed that brain-derived neurotrophic factor (BDNF), a
member of the neurotrophic factor family, may be implicated in the pathogenesis of ADHD.
This hypothesis is supported by recent genetic studies in ADHD. Drawing on findings from …
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